Folding by Chaperones Accelerates Evolutionary Dynamics
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003269 Multiscale models link NT mutations, PPIs & cell populations
Interesting discussion by Ken Dill reviewing the field of protein folding over the past 50 years. Dr Dill links it to a number of diseases such as Alzheimer’s, Parkinson’s and type II diabetes, which are transmitted by aberrantly folding proteins. There is also a bit of discussion about folding landscapes in the funnel.
http://www.sciencemag.org/content/338/6110/1042
The #Protein-Folding Problem, 50 Years On: Broad review, ranging from funnels to misfolded proteins & Alzheimer’s
http://www.sciencemag.org/content/338/6110/1042
The gist is that it is important for protein folding to choose optimal and non-optimal synonymous codons, at different locations.
http://www.nature.com/nsmb/journal/v20/n2/full/nsmb.2466.html
An interesting paper! Nice to see codon usage revisited again. Another revisiting of codons (my own) is at
http://papers.gersteinlab.org/papers/revisit-cai
Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding
Sebastian Pechmann & Judith Frydman
Nature Structural & Molecular Biology 20, 237–243 (2013) doi:10.1038/nsmb.2466
http://www.cell.com/abstract/S0092-8674(12)00509-0