Posts Tagged ‘cancer’
Clonal evolution in breast cancer revealed by single nucleus genome sequencing : Nature : Nature Publishing Group
Monday, October 13th, 2014Realizing the promise of cancer predisposition genes : Nature : Nature Publishing Group
Monday, October 13th, 2014Realizing the promise of cancer predisposition genes : Nature : Nature Publishing Group
http://www.nature.com/nature/journal/v505/n7483/full/nature12981.html
@markgerstein: .@rahman_nazneen mentions: Realizing the promise of cancer predisposition genes [of which there’s >100]
http://t.co/BbGNK6VJko #BTGCG14
Tracing the tumor lineage — ScienceDirect
Monday, October 13th, 2014@markgerstein: Navin mentions: Tracing the tumor lineage
http://t.co/pDTQBxmd54 Has nice schematic showing different tumor progression models #BTGCG14
http://www.sciencedirect.com/science/article/pii/S1574789110000323?via=ihub
OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes
Monday, October 13th, 2014@markgerstein: .nlbigas mentions: OncodriveCLUST: exploiting the [local] positional clustering of somatic mutations…
http://t.co/JbMYp6C7bF #BTGCG14
http://bioinformatics.oxfordjournals.org/content/29/18/2238.long
Access : Evolution of the cancer genome : Nature Reviews Genetics
Monday, October 13th, 2014@markgerstein: .@nlbigas mentions: Evolution of the cancer genome http://t.co/DLwrOlzqch Drivers provide selective advantage #BTGCG14
Criteria for Inference of Chromothripsis in Cancer Genomes — ScienceDirect
Monday, October 13th, 2014@markgerstein: Korbel mentions: Criteria for Inference of
Chromothripsis in Cancer Genome
http://t.co/TslcrZsmNv #BTGCG14
http://www.sciencedirect.com/science/article/pii/S0092867413002122
Analysis of noncoding regulatory mutations in cancer
Monday, September 29th, 2014http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3101.html
An interesting report of potential non-coding drivers without actually doing any wet lab work.
“These methods identify recurrent mutations in regulatory elements upstream of PLEKHS1, WDR74 and SDHD, as well as previously identified mutations in the TERT promoter”. In the text they mention “Khurana et al. also reported WDR74 promoter mutations in 2 of the 20 prostate cancer genomes analyzed”.
Constructing structural networks of signaling pathways on the proteome scale
Saturday, September 6th, 2014Structural networks of signaling pathways
http://www.sciencedirect.com/science/article/pii/S0959440X1200070X Prism on IL10 #networks, mapping on Cosmic, disrupting mutations as drivers
WIRED August 2014: The Price of Life
Monday, September 1st, 2014The Price of Life http://contentviewer.adobe.com/s/Wired/5857345fd35d4d1f9a1f00273013f68a/WI0814_10_Folio/2000_2208IN_deathvmoney.html Nice #visualization of NIH #funding, showing emphasis on #cancer & diabetes v heart disease