mRNA surveillance mitigates genetic dominance … Mol Gen Genet. 1998 – PubMed – NCBI
Saturday, July 19th, 2014Below is key ref.
## From Brenner talk at ISMB:
Argues that domain trunc prot have a dom. neg pheno.
(ex binding domain for reg & tf or sox10)
NMD fixes this; truncated case now looks like hemizyg.
## Related twitter dialogue:
Brenner: expl. how premature truncation is often a dominant neg. (ex SOX10), providing a rationalization for the purpose of NMD #ISMB #LBR01
@rtraborn · Jul 13
Why would cells generate mRNA that are then immediately degraded by NMD? Brenner suggests that this process has a regulatory function #ISMB
@raarjr · Jul 13
Brenner: 50 nt rule accurately predicts NMD, and is prevalent in auto regulation.so what’s our ruler? #ismb
## REF
http://www.ncbi.nlm.nih.gov/pubmed/9862469
Mol Gen Genet. 1998 Nov;260(2-3):176-84.
mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans.
Cali BM, Anderson P.