linkstream2 microblog

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003671

TADA tool, integrates evidence

Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes
Xin He,
Stephan J. Sanders,
Li Liu,
Silvia De Rubeis,
Elaine T. Lim,
James S. Sutcliffe,
Gerard D. Schellenberg,
Richard A. Gibbs,
Mark J. Daly,
Joseph D. Buxbaum,
Matthew W. State,
Bernie Devlin,
Kathryn Roeder

https://www.nature.com/neuro/journal/v18/n2/full/nn.3922.html
older stats approach

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways : Nature Neuroscience : Nature Research

https://www.ncbi.nlm.nih.gov/pubmed/11882781

QT:{{"
We find that over 600 positive associations between common gene variants and disease have been reported; these associations, if correct, would have tremendous importance for the prevention, prediction, and treatment of most common diseases. However, most reported associations are not robust: of the 166 putative associations which have been studied three or more times, only 6 have been consistently replicated.

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http://www.pnas.org/content/111/4/E455.abstract

https://www.ncbi.nlm.nih.gov/pubmed/10820966

https://www.ncbi.nlm.nih.gov/pubmed/22777127
has a nice plot showing heritability of these conditions

https://videocast.nih.gov/live.asp?live=24758&bhcp=1

https://en.wikipedia.org/wiki/Diagnostic_and_Statistical_Manual_of_Mental_Disorders

relies on categories

https://en.wikipedia.org/wiki/Emil_Kraepelin
SCZ v BPD

.@Genome_Gov Extramural Grant Portfolio
https://www.Genome.Gov/27569006/july-6-2017-the-nhgri-extramural-grant-portfolio-using-different-approaches-to-fund-genomics-research Nice grid divides programs into PI-initiated/consortia & RFA-solicited v not