A comprehensive review of genetic association studies. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/11882781
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We find that over 600 positive associations between common gene variants and disease have been reported; these associations, if correct, would have tremendous importance for the prevention, prediction, and treatment of most common diseases. However, most reported associations are not robust: of the 166 putative associations which have been studied three or more times, only 6 have been consistently replicated.
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