https://en.wikipedia.org/wiki/Howard_Martin_Temin
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Howard Martin Temin (December 10, 1934 – February 9, 1994) was a U.S. geneticistand virologist. He discovered reverse transcriptase in the 1970s[2] at the University of Wisconsin–Madison, for which he shared the 1975 Nobel Prize in Physiology or Medicine with Renato Dulbecco and David Baltimore.[3][4]
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The Avery–MacLeod–McCarty experiment was an experimental
demonstration, reported in 1944 by Oswald Avery, Colin MacLeod, andMaclyn McCarty, that DNA is the substance that causes bacterial transformation, in an era when it had been widely believed that it wasproteins that served the function of carrying genetic information (with the very word protein itself coined to indicate a belief that its function was primary).
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https://en.wikipedia.org/wiki/Theodor_Boveri
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Boveri’s work with sea urchins showed that it was necessary to have all chromosomespresent in order for proper embryonic development to take place. This discovery was an important part of the Boveri–Sutton chromosome theory. His other significant discovery was the centrosome (1888), which he described as the especial organ of cell division. Boveri also discovered the phenomenon of chromatin diminution during embryonic development of the nematode Parascaris.
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https://en.wikipedia.org/wiki/High-dose_chemotherapy_and_bone_marrow_transplant
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High–dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose … for megadose therapy in 1983. Frei and Peters developed the Solid Tumor Autologous Marrow Program (STAMP) regimen.
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high mutational burden predicts responsive patients