Charles David Allis – Wikipedia, the free encyclopedia
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Allis is best known for deciphering regulatory mechanisms that impinge upon the fundamental repeating unit of chromatin and for identifying the responsible enzyme systems that govern the covalent modifications of histone proteins, the principal components that organize chromatin. Allis discovered the critical link, through histone
acetyltransferase-containing transcriptional coactivators, between targeted histone acetylation and gene-specific transcriptional activation.
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