Evolution of…Enzyme Functions w/in Structural…Superfamilies http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002403 Most changes involve substrates rather than chemistry
develops functional change matrix…
based on 276 fams
Devious Defecator Case Tests Genetics Law http://www.nytimes.com/2015/06/02/health/devious-defecator-case-tests-genetics-law.html Non-obvious outcome of GINA protects employees from non-medical DNA testing
Apple now becoming so mainstream !
$IBM now offering employees Macs for the 1st time
http://9to5mac.com/2015/05/28/apple-ibm-macs-pc/ How can one THINK DIFFERENT when everyone has an $AAPL product?
High hopes http://www.sciencemag.org/content/345/6192/18.summary Resurgence interest in the medical benefits of #psychedelics. Is it possible to get them without the high?
America’s Epidemic of Unnecessary Care
http://www.newyorker.com/magazine/2015/05/11/overkill-atul-gawande QT: Facing a doctor, what are you going to fear: doing too little or too much?
Annals of Health Care MAY 11, 2015 ISSUE
Overkill
An avalanche of unnecessary medical care is harming patients physically and financially. What can we do about it?
BY ATUL GAWANDE
QT:{{”
Still, when it’s your turn to sit across from a doctor, in the white glare of a clinic, with your back aching, or your head throbbing, or a scan showing some small possible abnormality, what are you going to fear more—the prospect of doing too little or of doing too much?” …
“Right now, we’re so wildly over the boundary line in the other direction that it’s hard to see how we could accept leaving health care the way it is. Waste is not just consuming a third of health-care spending; it’s costing people’s lives. As long as a more thoughtful, more measured style of medicine keeps improving outcomes, change should be easy to cheer for. Still, when it’s your turn to sit across from a doctor, in the white glare of a clinic, with your back aching, or your head throbbing, or a scan showing some small possible abnormality, what are you going to fear more—the prospect of doing too little or of doing too much?”
“}}
How [to] Build a Safer Car?
http://www.newyorker.com/magazine/2015/05/04/the-engineers-lament QT: Pessimist sees glass as 1/2 empty; optimist, 1/2 full; engineer, 2X what it should be
Dept. of Transportation MAY 4, 2015 ISSUE
The Engineer’s Lament
Two ways of thinking about automotive safety.
BY MALCOLM GLADWELL
QT:{{”
There is an old joke about an engineer, a priest, and a doctor enjoying a round of golf. Ahead of them is a group playing so slowly and inexpertly that in frustration the three ask the greenkeeper for an explanation. “That’s a group of blind firefighters,” they are told. “They lost their sight saving our clubhouse last year, so we let them play for free.”
The priest says, “I will say a prayer for them tonight.”
The doctor says, “Let me ask my ophthalmologist colleagues if anything can be done for them.”
And the engineer says, “Why can’t they play at night?”
The greenkeeper explains the behavior of the firefighters. The priest empathizes; the doctor offers care. All three address the social context of the situation: the fact that the firefighters’ disability has inadvertently created conflict on the golf course. Only the engineer tries to solve the problem.
…
Almost all engineering jokes—and there are many—are versions of this belief: that the habits of mind formed by the profession enable engineers to see things differently from the rest of us. “A pessimist sees the glass as half empty. An optimist sees the glass as half full. The engineer sees the glass as twice the size it needs to be.” “}}
http://en.wikipedia.org/wiki/John_Vincent_Atanasoff
– early computer had mechanical rotating drums to keep capacitors charged – patent dispute w/ Mauchly over his visit – when is collaboration theft ?
[tag innovators,innovators0mg,turing0mg]
QT:{{”
John William Mauchly (August 30, 1907 – January 8, 1980) was an American physicist who, along with J. Presper Eckert, designed ENIAC, the first general purpose electronic digital computer, as well as EDVAC, BINAC and UNIVAC I, the first commercial computer made in the United States.
“}}
http://en.wikipedia.org/wiki/John_Mauchly
– ENIAC was v. big & fast
– funded for helping to calibrate artillery traj. in MD proving ground – played the scientist to Eckert, the engineer, & Goldstine, the funder
[tag innovators,innovators0mg,turing0mg]
described as a precursor to RAM