Archive for July, 2014
Drilling for Insight: NIH Funding for Biocomputing | Biomedical Computation Review
Saturday, July 12th, 2014Reference “Quantifying reproducibility in computational biolo…”
Friday, July 11th, 2014PLoS ONE, 2013 vol. 8(11) pp. e80278
Quantifying reproducibility in computational biology: the case of the tuberculosis drugome.
http://www.ncbi.nlm.nih.gov/pubmed/24312207
Garijo, D; Kinnings, S; Xie, L; Xie, L; Zhang, Y; Bourne, PE; Gil, Y
QT:{{
How easy is it to reproduce the results found in a typical computational biology paper? Either through experience or intuition the reader will already know that the answer is with difficulty or not at all. In this paper we attempt to quantify this difficulty by reproducing a previously published paper for different classes of users (ranging from users with little expertise to domain experts) and suggest ways in which the situation might be improved. Quantification is achieved by estimating the time required to reproduce each of the steps in the method described in the original paper and make them part of an explicit workflow that reproduces the original results. Reproducing the method took several months of effort, and required using new versions and new software that posed challenges to reconstructing and validating the results. The quantification leads to "reproducibility maps" that reveal that novice researchers would only be able to reproduce a few of the steps in the method, and that only expert researchers with advance knowledge of the domain would be able to reproduce the method in its entirety. ….
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.@pebourne Perhaps we need to educate biomedical data PhD students for more diverse careers #ismb #AFP14
The Second Machine Age: Work, Progress, and Prosperity in a Time of Brilliant Technologies:Amazon:Books
Friday, July 11th, 2014mentioned in Bourne talk, might be a good read
http://www.amazon.com/gp/aw/d/1480577472?pc_redir=1405002439&robot_redir=1
A Billionaire Mathematician’s Life of Ferocious Curiosity – NYTimes.com
Friday, July 11th, 2014PLOS Biology: The Ecology of Collective Behavior
Friday, July 11th, 2014#Ecology of Collective Behavior
http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001805 #Network structure reflects resource patchiness, operating costs & threat of rupture
The French Do Buy Books. Real Books
Friday, July 11th, 2014The French are not wrong in this respect.
http://mobile.nytimes.com/2014/07/10/opinion/pamela-druckerman-the-french-do-buy-books-real-books.html
Pseudogene expression in TCGA data
Friday, July 11th, 2014http://www.nature.com/ncomms/2014/140707/ncomms4963/full/ncomms4963.html
The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes
Leng Han
Yuan Yuan
Siyuan Zheng
Yang Yang
Jun Li
Mary E. Edgerton
Lixia Diao
Yanxun Xu
Roeland G. W. Verhaak
Han Liang