«
»

mRNA surveillance mitigates genetic dominance … Mol Gen Genet. 1998 – PubMed – NCBI

Below is key ref.

## From Brenner talk at ISMB:

Argues that domain trunc prot have a dom. neg pheno.
(ex binding domain for reg & tf or sox10)

NMD fixes this; truncated case now looks like hemizyg.

## Related twitter dialogue:

Brenner: expl. how premature truncation is often a dominant neg. (ex SOX10), providing a rationalization for the purpose of NMD #ISMB #LBR01

@rtraborn · Jul 13
Why would cells generate mRNA that are then immediately degraded by NMD? Brenner suggests that this process has a regulatory function #ISMB

@raarjr · Jul 13
Brenner: 50 nt rule accurately predicts NMD, and is prevalent in auto regulation.so what’s our ruler? #ismb

## REF

http://www.ncbi.nlm.nih.gov/pubmed/9862469

Mol Gen Genet. 1998 Nov;260(2-3):176-84.

mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans.

Cali BM, Anderson P.

Tags: , , , , , ,

This entry was posted on Saturday, July 19th, 2014 at 8:27 pm and is filed under SciLit, Uncategorized. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

One Response to “mRNA surveillance mitigates genetic dominance … Mol Gen Genet. 1998 – PubMed – NCBI”

  1. weight loss diet tips in urdu Says:
    September 20th, 2014 at 6:38 pm

    This is very fascinating, You arre an exxcessively skilled blogger.
    I’ve joined your rss feedd and sit up for seeking more of your great post.
    Also, I have shafed your site in my social networks

Leave a Reply