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http://www.nytimes.com/2014/01/02/opinion/edward-snowden-whistle-blower.html?pagewanted=all

Nature. 2013 Aug 29;500(7464):593-7. doi: 10.1038/nature12364. Epub 2013 Jul 28.

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing.

Xue Z, Huang K, Cai C, Cai L, Jiang CY, Feng Y, Liu Z, Zeng Q, Cheng L, Sun YE, Liu JY, Horvath S, Fan G.

QT:{{”
…We report here a comprehensive analysis of transcriptome dynamics from oocyte to morula in both human and mouse embryos, using single-cell RNA sequencing…. By weighted gene co-expression network analysis, we find that each developmental stage can be delineated concisely by a small number of functional modules of co-expressed genes. This result indicates a sequential order of transcriptional changes in pathways of cell cycle, gene regulation, translation and metabolism, acting in a step-wise fashion from cleavage to morula. Cross-species comparisons with mouse pre-implantation embryos reveal that the majority of human stage-specific modules (7 out of 9) are notably preserved, but developmental specificity and timing differ between human and mouse. Furthermore, we identify conserved key members (or hub genes) of the human and mouse networks.
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A paper on C. elegans that’s very informative:
http://www.nature.com/ng/journal/v44/n3/full/ng.1050.html
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity

Most notable of their findings is evidence of recent selective sweeps on chromosomes I, IV, V and (sort of) X. These sweeps have the potential to fix pseudogenes that might have been present at the time.

http://www.theglobeandmail.com//technology/how-insurers-are-turning-to-fitness-apps-to-decide-your-health-coverage/article16065068

http://mypdfmanuals.com/user-manual,ROBITUSSIN,DH-750,148813.pdf

Young Investigator for Ekta Khurana

http://www.genomeweb.com/genomeweb-feature-eighth-annual-young-investigators

.@neuromusic Great paper, out of my field. Wouldn’t have read if @sapinker hadn’t endorsed. The New #Statistics
http://pss.sagepub.com/content/early/2013/11/07/0956797613504966.abstract 1/3

.@neuromusic @sapinker Fig 1 shows how much more variable p-values are than CIs across simulated replicates, virtually no replication. (2/3)

.@neuromusic @sapinker Article argues strongly for meta-analysis & that we can get by with calculations for AIPE instead of power (3/3).

Admit that I’m inclined to the position taken by the medical literature to report CIs & p-values.

QT:{{”
Second, in response to renewed recognition of the severe flaws of null-hypothesis significance testing (NHST), we need to shift from reliance on NHST to estimation and other preferred techniques. The new statistics refers to recommended practices, including estimation based on effect sizes, confidence intervals, and meta-analysis.
…
I describe here a major problem of NHST that is too little recognized. If p reveals truth, and we replicate the experiment–doing everything the same except with a new random sample–then replication p, the p value in the second experiment, should presumably reveal the same truth. We can simulate such idealized replication to investigate the variability of p. Figure 1 depicts the simulated results of 25 replications of an experiment with two independent groups, each group having an n of 32. The population ES is 10 units of the dependent variable, or a Cohen’s δ of 0.50, which is conventionally considered a medium effect. Statistical power to find a medium-sized effect is .50, so the experiment is typical of what is published in many fields in psychology (Cohen, 1962; Maxwell, 2004).
…
The 95% CIs bounce around as we expect; they form the dance of the CIs. Possibly surprising is the enormous variation in the p value–from less than .001 to .75. It seems that p can take almost any value! This dance of the p values is astonishingly wide! You can see more about the dance at tiny.cc/dancepvals and download ESCI (Cumming, 2013) to run the simulation. Vary the population ES and n, and you will find that even when power is high–in fact, in virtually every situation–p varies dramatically (Cumming, 2008).
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http://pss.sagepub.com/content/early/2013/11/07/0956797613504966.long

http://www.nytimes.com/1996/06/11/science/biology-s-big-project-turns-into-challenge-for-computer-experts.html

Panasonic KX-TG9341T DECT 6.0 Expandable Digital Cordless Answering System http://service.us.panasonic.com/OPERMANPDF/KXTG9331.PDF
Had this for ~6 months. Nice headset & sound is good but headset batteries wear out quickly. Intuitive base station.
Takes batteries
http://www.amazon.com/Panasonic-Replacement-HHR-65AAABU-AAA-Pack/dp/B0031EHIX4 panasonic hhr 65aaabu ni-mh battery aaa

75 & Mad.
Open New Year’s Day
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