linkstream2 microblog

http://well.blogs.nytimes.com/2013/12/04/why-a-brisk-walk-is-better/?smid=tw-nytimes

Primate Transcript and Protein #Expression Levels Evolve Under Compensatory #Selection Pressures: [Protein]<[mRNA]
https://www.sciencemag.org/content/342/6162/1100

Are Isle Royale’s Wolves Chasing Extinction? Maybe from
#globalwarming; now population of ~10 wolves & ~1000 moose
http://www.sciencemag.org/content/340/6135/919.summary

Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions
L Ward & M Kellis
http://www.sciencemag.org/content/337/6102/1675.abs

In general we know that conservation across species and within humans are correlated. In this paper the authors focus on emphasize the exceptions to this trend. They show that although only ~5% of the human genome is conserved across mammals, regulatory regions in an additional 4% of the genomes are conserved amongst humans. They also show that some elements are conserved across mammals but lack functional activity from ENCODE data and also do not show purifying selection amongst humans. The authors pinpoint regulatory regions near color vision and nerve-growth genes for that show human-specific constraint. This has been criticized in various publications since there are other genes that are higher up in the authors’ list but harder to explain for lineage-specific constraint.

23andStupid: Is #23andMe Self-Destructing? Amazing it hasn’t communicated with the FDA since May. http://onforb.es/1el3YsQ MT @matthewherper

http://www.ncbi.nlm.nih.gov/pubmed/23176822
Am J Hum Genet. 2012 Dec 7;91(6):1033-40. doi:
10.1016/j.ajhg.2012.10.018. Epub 2012 Nov 21.
Differential relationship of DNA replication timing to different forms of human mutation and variation.
Koren A, Polak P, Nemesh J, Michaelson JJ, Sebat J, Sunyaev SR, McCarroll SA.

http://www.xconomy.com/san-francisco/2013/11/22/david-botstein-71-joining-googles-anti-aging-play-calico/

The Big Chill: Why Are American #Refrigerators So Big? Long cold chains & infrequent shopping
http://www.theatlantic.com/technology/archive/2013/10/the-huge-chill-why-are-american-refrigerators-so-big/280275 … #energy #environment

The Huge Chill: Why Are American Refrigerators So Big? – Jonathan Rees – The Atlantic

MT @Rbaltman Statins by Numbers http://nyti.ms/1bwpXzc Has medical #education prepared most doctors for the discipline’s money-ball moment?

http://www.nytimes.com/2013/11/30/opinion/statins-by-numbers.html

Diff betw. peer review of results v the actual code
http://www.sciencemag.org/content/340/6134/814.summary