The Mycobacterium tuberculosis regulatory network and hypoxia
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12337.html#
QT:”
We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration. …Using ChIP-Seq combined with expression
data from the induction of the same factors, we have reconstructed a draft regulatory network based on 50 transcription factors….The regulatory network reveals transcription factors
underlying these changes, allows us to computationally predict expression changes, and indicates that Rv0081 is a regulatory hub. “