linkstream2 microblog

Good quotes related to management hierarchies:
“Companies have been flattening out their management hierarchies in recent years, eliminating layers of middle management that can create bottlenecks and slow productivity.”
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The bossless structure can be chaotic at times, he says….
Since it was founded in 1958, W.L. Gore has operated under what it calls a “lattice” management structure, which relies on teams in place of bosses and traditional chains of command, and which was discussed by Malcolm Gladwell in his 2000 book “The Tipping Point.”
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http://online.wsj.com/article/SB10001424052702303379204577474953586383604.html

Nat. Methods. 2011 Aug; vol. 8(8) pp. 677-83
A large-scale method to measure absolute protein phosphorylation stoichiometries.
Wu R, Haas W, Dephoure N, Huttlin EL, Zhai B, Sowa ME, Gygi SP URL – http://www.ncbi.nlm.nih.gov/pubmed/21725298?dopt=Citation
Q: how does phosphorylation stoichiometry relate to the phosphorylome ? how many of the things are fully phosphorylated ?

http://www.ncbi.nlm.nih.gov/pubmed/21183079
A tissue-specific atlas of mouse protein phosphorylation and expression
interesting to intersect with mouse encode in relation to TFs & gene expression – how does it relate to cell lines ?

http://www.sciencemag.org/content/325/5948/1682.abstract

Relates to the lab’s rewiring paper (Shou et al.) and should have been cited as it has the same conclusion

http://www.nature.com/srep/2012/120329/srep00335/full/srep00335.html

http://www.nature.com/msb/journal/v8/n1/full/msb201199.html

http://www.nature.com/nbt/journal/v30/n2/full/nbt.2106.html?WT.ec_id=NBT-201202

Analysis of tweets using “inferred” networks
http://www.technologyreview.com/article/39294

http://www.sciencenews.org/view/generic/id/337088/title/Network_analysis_predicts_drug_side_effects