linkstream2 microblog

Comparative #genomics reveals insights into avian…#evolution http://www.sciencemag.org/content/346/6215/1311 Less repeats & dups in birds; woodpecker, an exception

Science 12 December 2014:
Vol. 346 no. 6215 pp. 1311-1320
DOI: 10.1126/science.1251385

Comparative genomics reveals insights into avian genome evolution and adaptation

Guojie Zhang1,2,*,†,
Cai Li1,3,*,
….
Avian Genome Consortium§,
Erich D. Jarvis20,†,
M. Thomas P. Gilbert3,56,†,
Jun Wang1,55,57,58,59,†

http://meetings.cshl.edu/meetings/2015/genome15.shtml
https://storify.com/markgerstein/favorite-tweets-from-bog15-i0bog15 http://linkstream2.gerstein.info/tag/i0bog15/

The evolutionary history of…metastatic prostate #cancer http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14347.html Unexpected: polyclonal "seeding" w/ much met-to-met spread

Transmissible Dog #Cancer #Genome Reveals…History of…Cell Lineage http://www.sciencemag.org/content/343/6169/437.abstract 1.9M somatic mutations from origin ~11K yrs ago

AACR 2015
http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=25#.VT8JXa1Viko http://linkstream2.gerstein.info/tag/i0pcawg15/

ISEV/ERCC Education Day – ISEV – International Society for
Extracellular Vesicles
http://www.isevmeeting.org/isevercc-education-day.html
http://linkstream2.gerstein.info/tag/i0isev/

2015 Bio-IT World Conference & Expo
http://www.bio-itworldexpo.com/
http://linkstream2.gerstein.info/tag/i0bioit15/
http://lectures.gersteinlab.org/summary/Progressive-summarization-large-scale-data-interpret-cancer–20150423-i0bioIT15/

8th International Conference on Ethics in Biology, Engineering & Medicine (ICEBEM 2015)
http://www.downstate.edu/orthopaedics/bioethics/
http://lectures.gersteinlab.org/summary/Soc-n-Tech-Soln-to-Privacy-in-Personal-Genomics–20150424-i0icebem15/

Tweets for all of them
https://storify.com/markgerstein/favorite-tweets-from-bioit-15-aacr-15-and-isev-15-16

The Race to Clone #BRCA1 http://www.sciencemag.org/content/343/6178/1462.abstract
Lessons on #LOF mutations, synthetic lethality, silly gene names & the 2-hit hypothesis

synthetic lethality (PARP inhibitors), gene names (RING fingers)

http://www.ncbi.nlm.nih.gov/pubmed/25477383

also
http://www.ncbi.nlm.nih.gov/pubmed/25477383
Nucleic Acids Res. 2015 Feb 27;43(4):e23. doi: 10.1093/nar/gku1252. Epub 2014 Dec 3.
Allele-specific copy number profiling by next-generation DNA sequencing. Chen H1, Bell JM2, Zavala NA2, Ji HP2, Zhang NR3.

perhaps related?

Make #precisionmedicine work for cancer http://www.nature.com/news/health-make-precision-medicine-work-for-cancer-care-1.17301 @MarkARubin1: >90% of…patients carry a mutation that may be drug-responsive

QT:{{"
“Hugely complicated genomic reports are rarely available in electronic form and are seldom tied to basic information about the patient. Whole-genome sequencing on tumour samples from nearly 14,000 people by the International Cancer Genome Consortium (ICGC), for instance, has revealed nearly 13 million mutations across the genome.

…
Since 2013, working with a team of computational biologists from Weill Cornell and the Centre for Integrative Biology at the University of Trento in Italy, my colleagues and I have conducted a pilot programme to determine the feasibility of tying genomic to clinical data in real time. So far, we have created easy-to-read reports for 250 people with cancer.
…
We have discovered that more than

"more than 90% of our patients carry a mutation that may be responsive to a known drug — although less than 10% of the patients may be eligible for a clinical trial either for logistical reasons or because there is insufficient evidence to warrant trying a non-approved drug.”
"}}

Landscape of oncogenic signatures across human #cancers
http://www.nature.com/ng/journal/v45/n10/full/ng.2762.html Disjoint types dominated by copy number changes or mutations

pp1127 – 1133

Giovanni Ciriello, Martin L Miller, Bülent Arman Aksoy, Yasin Senbabaoglu, Nikolaus Schultz & Chris Sander

doi:10.1038/ng.2762

Chris Sander and colleagues have extracted significant functional events from 12 tumor types. Tumors can be classified as being driven largely by either mutation or copy number changes, and, within this division, subclasses of cross-tissue patterns of events are discerned that suggest sets of combinatorial therapies.

Roche Sequencing acquires Bina Technologies
https://www.genomeweb.com/business-news/roche-acquires-bina-technologies Wow: 454, Nimblegen & now Bina! (NB: I’ve consulted for Bina & 454.)