linkstream2 microblog

http://ecerami.github.io/vogelstein-v-lander-round1.html
Short list of 140 drivers v an ever growing list

Science. 2013 Mar 29;339(6127):1546-58. doi: 10.1126/science.1235122. Cancer genome landscapes.
Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW. QT:”
To date, these studies have revealed ~140 genes that, when altered by intragenic mutations, can promote or “drive” tumorigenesis. A typical tumor contains two to eight of these “driver gene” mutations; the remaining mutations are passengers that confer no selective growth advantage. Driver genes can be classified into 12 signaling pathways that regulate three core cellular processes: cell fate, cell survival, and genome maintenance.
”

Lessons from the Cancer Genome
http://www.cell.com/abstract/S0092-8674(13)00288-2
QT:”
Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not previously known to be causal targets in cancer. “

http://www.nytimes.com/2013/05/02/health/dna-research-points-to-new-insight-into-cancers.html?pagewanted=all&_r=0

http://ecerami.github.io/vogelstein-v-lander-round1.html

http://www.nature.com/nature/journal/v497/n7447/full/nature12065.html

http://www.nytimes.com/2013/04/22/health/patients-genes-seen-as-future-of-cancer-care.html Features new WCMC Belfer building

http://www.nytimes.com/2013/04/28/business/in-cancer-treatment-new-dna-tools.html?smid=tw-nytimesscience&seid=auto&_r=0

http://www.nytimes.com/2013/04/22/health/patients-genes-seen-as-future-of-cancer-care.html

http://www.nature.com/ng/journal/v45/n4/full/ng.2560.html?WT.ec_id=NG-201304

Nat Biotechnol. 2012 May;30(5):413-21. doi: 10.1038/nbt.2203. Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G.

http://www.nytimes.com/2013/01/25/science/new-mutations-discovered-in-melanomas.html
Two papers in Science talking about recurrent mutations in TERT promoter in melanoma.

1) http://www.sciencemag.org/content/339/6122/957.full
Highly Recurrent TERT Promoter Mutations in Human Melanoma
Franklin W. Huang1,2,3,* Eran Hodis1,3,4,*,Mary Jue Xu1,3,4,Gregory V. Kryukov1,Lynda Chin5,6,Levi A. Garraway1,2,3,†

2) http://www.sciencemag.org/content/339/6122/959.full
TERT Promoter Mutations in Familial and Sporadic Melanoma
Susanne Horn1,2,Adina Figl1,2,P. Sivaramakrishna Rachakonda1,Christine Fischer3,Antje Sucker2,Andreas Gast1,2,Stephanie Kadel1,2,Iris Moll2,Eduardo Nagore4,Kari Hemminki1,5,Dirk Schadendorf2,*,†,Rajiv Kumar1,*,†