Widespread transcription at neuronal activity-regulated enhancers : Nature : Nature Publishing Group
Sunday, July 29th, 2012Findings on eRNAs
http://www.nature.com/nature/journal/v465/n7295/full/nature09033.html
Archive for the ‘SciLit’ Category
SIAM: M.C. Escher: More Mathematics Than Meets the Eye
Saturday, July 28th, 2012A Whole-Cell Computational Model Predicts Phenotype from Genotype
Saturday, July 21st, 2012from JC :
http://www.cell.com/abstract/S0092-8674(12)00776-3
Jonathan R. Karr, Jayodita C. Sanghvi, Derek N. Macklin, Miriam V. Gutschow, Jared M. Jacobs, Benjamin Bolival, Nacyra Assad-Garcia, John I. Glass, Markus W. Covert
Cell – 20 July 2012 (Vol. 150, Issue 2, pp. 389-401)
Accelerated regions in human and brain function
Thursday, July 19th, 2012evolutionary role for pervasive transcription: de novo gene birth
Thursday, July 19th, 2012Proto-genes and de novo gene birth
http://www.nature.com/nature/journal/v487/n7407/full/nature11184.html
Cell – Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers
Saturday, July 14th, 2012http://www.cell.com/retrieve/pii/S009286741200640X?cc=y
Transcribed pgenes perhaps acting as ceRNAs very tissue specific, in a variety of cancers
Most less conservative threshold on calling transcription than in encodeprodpgenes
Cell – The Genetic Basis for Cancer Treatment Decisions
Thursday, July 5th, 2012http://www.cell.com/abstract/S0092-8674(12)00020-7
T Hudson et al.
Landscape of Somatic Retrotransposition in Human Cancers – Science
Thursday, July 5th, 2012http://www.sciencemag.org/content/early/2012/06/27/science.1222077.abstract
Park lab led analysis of TCGA data
Massively parallel functional dissection of mammalian enhancers in vivo – Nature Biotech
Thursday, July 5th, 2012http://www.nature.com/nbt/journal/v30/n3/full/nbt.2136.html
Note: “the functional consequences of most mutations was modest”.
Nature The evolution of gene expression levels in mammalian organs – Kaessmann
Thursday, July 5th, 2012http://www.nature.com/nature/journal/v478/n7369/pdf/nature10532.pdf [tag comparativetranscriptomics]