Side-chain theory – Wikipedia, the free encyclopedia

Borrowing a concept used by Emil Fischer in 1894 to explain the interaction between an enzyme and its substrate, Ehrlich proposed that binding of the receptor to an infectious agent was like the fit between a lock and key. He published the first part of his side-chain theory in 1897, and its full form in 1900 in a lecture he delivered to the Royal Society in London.[4]



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