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PLOS Computational Biology: Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies

Evolution of…Enzyme Functions w/in Structural…Superfamilies http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002403 Most changes involve substrates rather than chemistry

develops functional change matrix…
based on 276 fams

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