Emerging landscape of oncogenic signatures across human cancers
Landscape of oncogenic signatures across human #cancers
http://www.nature.com/ng/journal/v45/n10/full/ng.2762.html Disjoint types dominated by copy number changes or mutations
pp1127 – 1133
Giovanni Ciriello, Martin L Miller, Bülent Arman Aksoy, Yasin Senbabaoglu, Nikolaus Schultz & Chris Sander
doi:10.1038/ng.2762
Chris Sander and colleagues have extracted significant functional events from 12 tumor types. Tumors can be classified as being driven largely by either mutation or copy number changes, and, within this division, subclasses of cross-tissue patterns of events are discerned that suggest sets of combinatorial therapies.