Mutational heterogeneity in cancer and the search for new cancer-associated genes Nature. 2013 – PubMed – NCBI
http://www.ncbi.nlm.nih.gov/pubmed/23770567
Lawrence et al. Nature (2013)
Mutational heterogeneity in cancer and the search for new
cancer-associated genes
Mutational heterogeneity in #cancer: #Mutation rate correlated with replication timing & transcription
http://www.nature.com/nature/journal/v499/n7457/full/nature12213.html #genomics
QT:”
We apply MutSigCV to exome sequences from 3,083 tumour–normal pairs and discover extraordinary variation in mutation frequency and spectrum within cancer types, which sheds light on mutational processes and disease aetiology, and in mutation frequency across the genome, which is strongly correlated with DNA replication timing and also with transcriptional activity.
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