Predicting the Binding Patterns of Hub Proteins: A Study Using Yeast Protein Interaction Networks
used the singlish/multi concept. Then used machine learning to predict whether a protein is singlish or multi
PLOS ONE
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056833
Taner Z. Sen