linkstream2 microblog

http://9to5mac.com/2012/12/11/review-moleskines-30-evernote-large-ruled-smart-notebook-for-ios-and-giveaway/#more-253321

BBC article:
http://www.bbc.co.uk/news/science-environment-20617312

http://www.cell.com/AJHG/fulltext/S0002-9297%2812%2900538-1
Deleterious- and Disease-Allele Prevalence in Healthy Individuals: Insights from Current Predictions, Mutation Databases, and
Population-Scale Resequencing
Yali Xue1, Yuan Chen1, Qasim Ayub1, Ni Huang1, Edward V. Ball2, Matthew Mort2, Andrew D. Phillips2, Katy Shaw2, Peter D. Stenson2, David N. Cooper2, Chris Tyler-Smith1, , and the 1000 Genomes Project Consortium

http://www.ncbi.nlm.nih.gov/pubmed/23247980

the fate of Thera Flu!
http://www.huffingtonpost.com/2012/04/18/johnson-johnsons-tylenol-_n_1434660.html

http://genome.cshlp.org/content/early/2012/11/01/gr.141382.112
analysis of 95 tumor genomes

>$1k/yr for subs to Times & Journal, isn’t sustainable for avg. incomes of $50k/yr
http://www.newyorker.com/online/blogs/johncassidy/2012/12/memo-to-murdoch-and-sulzberger-you-are-now-luxury-goods-manufacturers.html

QT:”
Bread wheat (Triticum aestivum) is a globally important crop, accounting for 20 per cent of the calories consumed by humans….Here we report the sequencing of its large, 17-gigabase-pair, hexaploid genome using 454 pyrosequencing, and comparison of this with the sequences of diploid ancestral and progenitor genomes. We identified between 94,000 and 96,000 genes.
”
http://www.nature.com/nature/journal/v491/n7426/full/nature11650.html?WT.ec_id=NATURE-20121129

Bioinformatics. 2012 Jan 1;28(1):56-62. doi:
10.1093/bioinformatics/btr614. Epub 2011 Nov 8.
Epigenetic priors for identifying active transcription factor binding sites. Cuellar-Partida G, Buske FA, McLeay RC, Whitington T, Noble WS, Bailey TL.

Score (posterior, at position i in the genome) = PWM for TF t at position i + priors at i (H3K4me + Dnase), gets 60% sens. at FPR of 1% averaged over all i & t, using essentially equal weighting on each functional genomics track. One issue here is because of the huge size of the genome the 1% FPR actually turns into a very low PPV, giving 5 FPs for each TP in practice.
http://www.ncbi.nlm.nih.gov/pubmed/22072382

http://ascr-discovery.science.doe.gov/exascale/exa_fault1.shtml

QT:”
After a battery is inserted, FOFA will beep and go into the Simple Setup. The LED will begin flashing – FOFA now wants to know what number you want it to be assigned to (1 through 6). Press a single number to program the FOFA to that number. FOFA will now flash and “beep back” your choice to confirm what you selected.
”
http://www.findonefindall.com/fofaXDOMback.pdf