Mutational Signatures of De-Differentiation in Functional Non-Coding Regions of Melanoma Genomes
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002871 QT:”
To understand the functional impact of non-coding somatic variation, we leveraged functional data generated by the ENCODE Project Consortium. We analyzed regulatory regions derived from multiple different cell types and found that melanocyte-specific regions are among the most depleted for somatic mutation accumulation.
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