linkstream2 microblog

https://www.scientificamerican.com/article/huge-brain-study-uncovers-buried-genetic-networks-linked-to-mental-illness/

https://news.yale.edu/2018/12/13/developing-brain-scientists-find-roots-neuropsychiatric-diseases

yale press release

The papers are out!
Using the tag pecrollout for this.
http://science.sciencemag.org/content/362/6420/1227

QT: {{”
The project’s namesake, ENCODE (Encyclopedia of DNA Elements), was a broader quest to map noncoding regions of the human genome. Its initial results, unveiled in 2012, stirred controversy. Scientists disputed the team’s claim that most of the genome was functional and questioned whether the project’s insights would be worth NIH’s $185 million investment (Science, 21 March 2014, p. 1306).
“}}

https://www.sciencenews.org/article/big-data-how-when-where-mental-disorders-start-brain

The papers are out!
Using the tag pecrollout for this.
http://science.sciencemag.org/content/362/6420/1227

QT: {{”
The project’s namesake, ENCODE (Encyclopedia of DNA Elements), was a broader quest to map noncoding regions of the human genome. Its initial results, unveiled in 2012, stirred controversy. Scientists disputed the team’s claim that most of the genome was functional and questioned whether the project’s insights would be worth NIH’s $185 million investment (Science, 21 March 2014, p. 1306).
“}}

https://www.nytimes.com/2018/11/19/health/mental-health-psychology.html

TWAS of 229k women identifies new candidate susceptibility genes for breast cancer https://www.Nature.com/articles/s41588-018-0132-x Metascan approach. Derive model for imputing transcriptome from #GTEx & validate against TCGA. Application to BCAC.

Genome-wide prediction & functional characterization of the genetic basis of autism spectrum disorder, by @OlgaTroyanskaya lab
https://www.Nature.com/articles/nn.4353 Intersected candidate #ASD genes w/ #BrainSpan gene expression to find a pre-natal signal for the disease

http://www.sciencemag.org/news/2016/03/alzheimer-s-may-be-caused-haywire-immune-system-eating-brain-connections

Alzheimer’s may be caused by haywire immune system eating brain connections Study targets new mechanism in fight against cognitive decline

https://www.nature.com/articles/nature25980

A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

Suijuan Zhong
, Shu Zhang
[…]
Xiaoqun Wang
Nature
doi:10.1038/nature25980