Common SNPs explain a large proportion of the heritability for human height : Nature Genetics : Nature Research
http://www.nature.com/ng/journal/v42/n7/abs/ng.608.html
Common SNPs explain a large proportion of the heritability for human height
Jian Yang,
Beben Benyamin,
Brian P McEvoy,
Scott Gordon,
Anjali K Henders,
Dale R Nyholt,
Pamela A Madden,
Andrew C Heath,
Nicholas G Martin,
Grant W Montgomery,
Michael E Goddard
& Peter M Visscher
Nature Genetics 42, 565–569 (2010) doi:10.1038/ng.608
QT:{{"
…conveniently implemented with a mathematically equivalent model
that uses the SNPs to calculate the genomic relationship between
pairs of subjects). Using this approach, we estimated the proportion
of phenotypic variance explained by the SNPs as 0.45 (s.e. = 0.08,
Table 1), a nearly tenfold increase relative to the 5% explained by
published and validated individual SNPs
"}}
Common SNPs explain a large proportion (45%) of heritability for…height (80%) http://www.Nature.com/ng/journal/v42/n7/abs/ng.608.html Vs ’10 GWAS SNPs could only expl. 5%