linkstream2 microblog

https://nihrecord.nih.gov/newsletters/2016/01_29_2016/story1.htm

.@dataparasite @KaminskiMed @atulbutte @NEJM Thought the recent @ISCB response on #researchparasitism was good
http://news.iscb.org/2016/01/iscb-responds-to-new-england-journal-of.html
http://news.iscb.org/2016/01/iscb-responds-to-new-england-journal-of.html

http://www.nature.com/news/google-ai-algorithm-masters-ancient-game-of-go-1.19234

http://www.nytimes.com/2016/01/28/health/schizophrenia-cause-synaptic-pruning-brain-psychiatry.html?_r=0

http://europepmc.org/articles/PMC4702932/

.@fionabrinkman @BioMickWatson @iddux Spurious Correlations
(http://tylervigen.com/spurious-correlations) related to Stat Frankenstein (https://twitter.com/markgerstein/status/689478730343837696)

Great #timelapse movies of #blizzard2016:
Snow piling up in VA

Timelapse video shows the snow piling up in Virginia during #blizzard2016 https://www.youtube.com/watch?v=r_g5IAD_4Pg

Winter Wonderland in Manhattan’s Heart
http://www.nytimes.com/video/nyregion/100000004165152/winter-wonderland-in-manhattans-heart.html Great time-lapse #movie of the progression of #blizzard2016

QT:{{”
Snowflakes started falling at Central Park on Friday night, forming a smooth white blanket that by Sunday would wrap the area in the pristine quiet of winter.
“}}

Spatial genomic heterogeneity w/in…prostate #cancer
http://www.nature.com/ng/journal/v47/n7/full/ng.3315.html WGS analysis of many sites suggests divergent tumor evolution

Boutros…, van der Kwast, Bristow (2015) “Spatial genomic
heterogeneity within localized, multi-focal prostate cancer” Nature Genetics 47(7):736-745 (PMID: 26005866)

This work represents the first systematic relation of intraprostatic genomic heterogeneity to predicted clinical outcomes at the level of whole-genome sequencing (WGS). Five patients, with index tumors of Gleason score 7, were subjected to a WGS protocol with spatial sampling of 23 distinct tumor regions to assess intraprostatic heterogeneity. In their analysis, Boutros et al, discovered recurrent amplification of MYCL, which is associated with TP53 loss. This finding is one of the first clear functional distinctions between MYC family members in prostate cancer and suggests that MYCL amplification may be preferentially localized in the index lesion. Overall, the authors believe their results are useful in the development of prognostic biomarkers that are necessary to achieve personalized prostate cancer medicine. It is important to note that such diagnostic biopsy protocols can miss regions of more aggressive cancers resulting in the patient being under-staged.

Winter Wonderland in Manhattan’s Heart
http://www.nytimes.com/video/nyregion/100000004165152/winter-wonderland-in-manhattans-heart.html Great time-lapse #movie of the progression of #blizzard2016

QT:{{”
Snowflakes started falling at Central Park on Friday night, forming a smooth white blanket that by Sunday would wrap the area in the pristine quiet of winter.
“}}

Inflamed by @Groopman
http://www.newyorker.com/magazine/2015/11/30/inflamed #Medicine’s Burning Q: Is inflammation the root of all problems or just a correlate to them?