The genomic landscape of Neanderthal ancestry in present-day humans : Nature : Nature Publishing Group

The genomic landscape of #Neanderthal ancestry in…humans
http://www.nature.com/nature/journal/v507/n7492/full/nature12961.html Regions enriched & depleted in ancient alleles, from 1000G

1004 indiv. => 1000G phase 1

QT:{{”
Here, we have systematically inferred Neandertal haplotypes in the genomes of 1,004 present-day humans. Regions that harbor a high frequency of Neandertal alleles in modern humans are enriched for genes affecting keratin filaments suggesting that Neandertal alleles may have helped modern humans adapt to non-African environments. Neandertal alleles also continue to shape human biology, as we identify multiple Neandertal-derived alleles that confer risk for disease. We also identify regions of millions of base pairs that are nearly devoid of Neandertal ancestry and enriched in genes, implying selection to remove genetic material derived from Neandertals. “}}

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